We explored how extracts from elderflower, rich in phytoestrogens, influence hormone production and the behavior of certain cancer cells, particularly focusing on breast cancer. The study involved culturing trophoblast tumor cells and MCF7 breast cancer cells, exposing them to various concentrations of elderflower extracts while keeping some as untreated control groups. By measuring hormone levels and assessing receptor expressions, we obtained a clearer picture of the extracts’ effects.
The findings revealed that elderflower extracts significantly inhibited the production of estradiol, a key hormone, in all cell types tested. Interestingly, we noted an increase in estrogen receptor (ER) expression in one type of trophoblast cell (JEG-3) and a decrease in ER expression along with an upregulation of progesterone receptor (PR) expression in MCF7 cells. This dual action presents a more complex interaction than initially anticipated, suggesting the potential of elderflower extracts in breast cancer prevention and treatment.
It’s worth noting that while enterolactone and enterodiol, also tested in the study, displayed different effects by inhibiting both ER and PR expression, elderflower extracts showed promising results by specifically affecting hormone levels and receptor expressions. Although the full therapeutic potential of elderflower remains to be confirmed through further investigation, these early findings provide a hopeful glimpse at how this natural extract might play a role in breast cancer care.